Hermann is on the Missouri River at the crossroads of Highways 19 and 100.

From St. Louis/St. Charles County: Take I-70 west to Highway 19 (Exit 175), go 15 miles south to Hermann. 

From St. Louis/South St. Louis County: Take I-44 west to Highway 100 (Exit 251), go west 38 miles to Hermann.

From Springfield, MO/ Fort Leonard Wood area: Take I-44 east to Highway 19 (Exit 208), go north 50 miles to Hermann. 

From Kansas City/Columbia: Take I-70 east to Highway 19 (Exit 175), go 15 miles south to Hermann.

From Jefferson City: Take Highway 54 East to I-70 east, to Highway 19 (Exit 175), go 15 miles south to Hermann; or take Highway 94 to Highway 19, turn right (south) and go one mile into Hermann.

From Katy Trail: From McKittrick Trailhead take Highway 19 south 2 miles and cross bridge into Hermann.